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Other immune factors, including abnormal natural killer cell activity or alloimmune reactions, are less well established and are actively being studied

KPV has the most direct evidence for dermatitis and addresses both inflammation and microbial defense

Trial investigators and participants were unaware of patients' allocation into groups during the trial

This can help reduce misdiagnosis or overdiagnosis

For a patient friendly primer, see the patient friendly overview from the Cleveland Clinic explaining what nicotinamide adenine dinucleotide is and the essential role it plays in how every cell produces energy, and to understand what an in clinic protocol actually delivers, read our detailed guide to what an IV NAD+ protocol actually does inside your cells and the wellness benefits patients most commonly notice over a course of treatment