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Experimental studies demonstrated that PLTs can be activated via pharmacological inhibition of endogenous NO production in humans (159), leading to hypercoagulability and thrombotic complications (186)

3.1 NF-B pathway The NF-B pathway serves as a pivotal regulator of inflammatory responses, activated by various stimuli such as pro-inflammatory cytokines (e.g., TNF- and IL-1), microbial components, and oxidative stress (Singh and Singh, 2020)

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Evaluation of the efficacy, safety, and tolerability of BI 409306, a novel phosphodiesterase 9 inhibitor, in cognitive impairment in schizophrenia: a randomized, double-blind, placebo-controlled, phase II trial