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Alzheimers and Parkinsons disease

Diabetes Care 46 , 101110 (2023)

Mitochondrial 5-demethoxyubiquinone hydroxylase (COQ7), a soluble protein found on the matrix side of the IMM, is a conserved enzyme essential for ubiquinone biosynthesis

Studies have shown impaired antioxidant functions connected to the onset and progression of numerous diseases 5

The recent descriptions of a polymorphism in the oxidation of trimethylamine, believed to be metabolized largely by the flavin monooxygenase (Ziegler's enzyme), suggest that genetic variants of other non-P450-dependent oxidative enzymes may also contribute to such polymorphisms