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Int J STD AIDS 28:744749

But one of the best indirect As(III) sensors is reported in recent time

Higher ROS levels are also linked to higher levels of viral infection and replication

Trypanosomatid nucleus and kinetoplast display topoisomerases that show significant structural differences from host orthologs advocating their potential as drug targets [143]

Glutathione exists in its oxidized (GSSG) and its reduced (GSH) form and plays a major role in regulating ROS concentrations within the cytoplasm, both directly as a free-radical scavenger and indirectly as a substrate with NADPH for detoxifying ROS (Guerin et al., 2001)