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Finally, we assessed the biological effects of PAP-CYS and APAP-CYS conjugates

Figure 4 shows that this inhibition has the effect that is expected at steady state

After recent debunking[18-20] of that long-standing belief, mitochondrial dysfunction has instead been attributed as the main source of free radicals and oxidative stress in paracetamol hepatotoxicity[21]

2.2 Synthesis methods of MOFs 2.2.1 Hydrothermal or solvothermal synthesis Hydrothermal refers to a chemical reaction that occurs in the presence of water (a dipole proton solvent) at a temperature higher than the boiling point and under a pressure greater than 1 atmosphere

STA-Sankey network diagrams of D-Amino acid metabolism, beta-Alanine metabolism, Peptidoglycan biosynthesis, Lysine biosynthesis and Sulfur metabolism have been shown in Figure S4