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Under stress conditions, mitochondrial damage results in the production of excessive mtROS, provoking oxidative damage to mtDNA and mtDNA release into the cytoplasm through the mitochondrial permeability transition pore, which further activates the DNA sensor cGAS-STING and facilitates downstream inflammatory processes (101, 102)

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Efficient predictor for immunotherapy efficacy: detecting pan-clones effector tumor antigen-specific T cells in blood by nanoparticles loading whole tumor antigens

K., & Godugu, C

Nutritional reset of immune impairment SARS-CoV-2 infection triggers immune response, a regular host defense strategy to restrain viral entry and constrain disease progression