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Diagnosing Rheumatoid Arthritis The diagnosis of RA is based upon multiple factors (Agarwal, 2011): a patient's history of joint pain and stiffness a physical exam documenting symmetrical (on both sides equally) joint swelling ( synovitis ) The wrists, and joints in the hands & feet are most commonly involved Morning stiffness lasting more than an hour suggests an inflammatory etiology (Wasserman, 2011)

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Discovery and functional characterization of a potent, selective, and metabolically stable PROTAC of the protein kinases DYRK1A and DYRK1B

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