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doi:10.1017/S1461145711000617 Gigante AD, Bond DJ, Lafer B, Lam RW, Young LT, Yatham LN (2012) Brain glutamate levels measured by magnetic resonance spectroscopy in patients with bipolar disorder: a meta-analysis

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Based on clinical features and prognosis, HRS is classified into type 1 and 2, type 1 is associated with poor prognosis

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The liver contains the greatest diversity and quantity of metabolic enzymes involved in the biotransformation of drugs, and thus the majority of drug metabolism occurs in the liver