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2 Mechanisms of hypoxia in the tumor microenvironment 2.1 Development of hypoxia in tumors Hypoxia is a common feature observed in approximately 90% of solid tumors and is widely recognized as a hallmark of cancer ( Figure 3 ) ( Figure 3 Hypoxia in tumors can be broadly categorized into two distinct forms: chronic hypoxia and acute (or cycling) hypoxia ( In contrast, acute hypoxia, also referred to as cycling or intermittent hypoxia, arises due to transient fluctuations in tumor blood flow ((no longer than 24 h))., leading to to oxygen levels below 1% that can be reversed with returned blood flow (24)

Stay Hydrated The adrenal glands secrete a hormone called aldosterone (ALD), which is responsible for regulating blood pressure by managing sodium and potassium levels

12(8): 2476 (2020) Liu Y, Tran DQ, Rhoads JM

Tanshinone IIA accomplished protection against radiation-induced cardiomyocyte injury by regulating the p38/p53 pathway