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Ind J Pharma

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Given that SORLA inhibits amyloidogenic processing of APP [8], we next investigated whether the increased SORLA levels observed in the brains of auranofin-treated mice would result in reduced BACE1-mediated cleavage of APP and decreased A generation

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In this study, correlations were found between antioxidant enzyme activities and pesticide concentrations (Table III), SOD activity was correlated with -HCH and cyclodienes content (r = 0.45 and r = 0.39, respectively), GPx activity was correlated with concentrations of -HCH and chlordanes (r = 0.35 and r = - 0.36, respectively), and GR activity was correlated with aldrin concentration (r = - 0.50)