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Specific groups of people need to take vitamin B12 shots, such as Vegetarians and Vegans, older adults, individuals with gastrointestinal conditions, people with pernicious anaemia, pregnant and breastfeeding women, and individuals with symptoms of deficiency

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Hypoxia and immunosuppressive factors in the TME can impair DC function, whereas autophagy maintains DC activity through multiple mechanisms: on one hand, it degrades senescent mitochondria and damaged proteins within DCs, preserving energy homeostasis and reducing ROS-induced apoptosis to safeguard DC numbers