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Intriguingly, reduction of fasting plasma BCAAs levels alone is insufficient to improve insulin sensitivity, suggesting a potentially synergistic role of multiple tissues in modulating BCAAs metabolism to alter insulin responsiveness (Blair et al., 2023)

Diabetes 12 , 14631478 (2021)

Nature 443 , 590593 (2006)

Drugs inducing high levels of ROS involve camptothecins, anthracyclines (doxorubicin, daunorubicin), Pt-based drugs, and others (Brezova et al

Synthesizing these findings, we outline emerging combination strategies that concurrently target ferroptosis and cuproptosis, and discuss current challenges and future directions for translating these concepts into precision therapies for OSCC