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Sr-05000001875 193

To enhance the practical applicability of this framework, future research should also address the heterogeneity in dosing, treatment duration, and patient phenotypes observed across existing studies

Importantly, the continuous elevation of endogenous O 2 levels by CAT suppressed the expression of HIF-1 in both normoxia (21% O 2 ) and hypoxia conditions (1% O 2 , Fig