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These factors trigger the upregulation of adhesion molecules ICAM-1 and VCAM-1 through NF-B-mediated inflammatory pathways, facilitating the migration of immune cells into the vessel walls and promoting foam cell formation and plaque development

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10.3389/fimmu.2024.1378990 197 WangL.ZhuY.ZhangL.GuoL.WangX.PanZ.et al (2023d)

Diseases associated with glutathione peroxidase 4 (GPX4) are often associated with Sedaghatian-type spondylometaphyseal dysplasia, and Nrf2 superactivity is a multisystem disorder characterized by hypohomocysteinemia, failure to thrive, immunodeficiency, and neurodevelopmental abnormalities

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