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It mediates most of the systemic effects of growth hormone through agonism at the IGF-1 receptor (IGF-1R), a transmembrane tyrosine-kinase receptor expressed on most tissues

doi: 10.1038/s41591-021-01292-y 171 ChenCHaupertSRZimmermannLShiXFritscheLGMukherjeeB

Thus, further studies must be conducted in the future to address these challenges