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BPA also promoted hepatic ferroptosis by increasing iron accumulation and upregulating genes associated with lipid peroxidation, while downregulating key antioxidant-related genes such as GPX4 , SLC7A11 , and SLC3A2

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Time- and dose-related improvements in insulin sensitivity were similar to the temporal patterns of body weight loss with retatrutide in both the MASLD cohort reported here and in the full cohort of people with obesity 13