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In general, TRPM channels are non-selective Ca 2+ -permeable channels or regulate Ca 2+ entry indirectly

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Each JMJ subfamily has distinct histone targets: for instance, KDM4 (JMJD2A-D) enzymes demethylate H3K9me3 (a heterochromatin mark) and H3K36me3 (an active mark), implying that they can either activate or repress transcription depending on context

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