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[37] [38] Chronic consumption of paracetamol is in many cases not of benefit, [25] and may result in abnormal liver function tests, and higher doses may lead to toxicity, including liver failure

107 Therefore, analogs of ferrostatin-1, such as UAMC-3203, have been developed with improved stability and higher efficacy in inhibiting ferroptosis

doi: 10.1038/s41419-021-03452-x 133 DuttaRKKondetiVKSharmaIChandelNSQuagginSEKanwarYS

Functionally, this predicted cleavage site is only 5 residues from the C terminal of TXNRD1, and would result in removal of the C-terminal redox center of TXNRD1 (AGCUG), making the enzyme incapable of regenerating reduced thioredoxin

Abbreviations: LPS, Lipopolysaccharide