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The most compelling evidence suggesting that ROS may increase cancer risk has been confirmed by the knockout of O 2 scavenging enzymes, such as cytoplasmic Cu, Zn-SOD null mice, or mitochondrial Mn-SOD null mice, resulting in significant oxidative damage and a propensity to develop cancer spontaneously (Gill et al

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This suggests that long-term inflammation plays a part in how endometriosis starts and gets worse (3)

Pre-clinical studies using VitC in combination with chemotherapy and radiation therapy In pre-clinical models, high-dose VitC is reported to enhance the effectivity of a wide variety of chemotherapeutics such as carboplatin [63, 89], cisplatin [51, 89, 100,101,102,103, 179, 180], chlorambucil [181], 5-FU [88, 89, 182], gemcitabine [14, 110, 183, 184] and temozolomide [16, 54] in various cancer cell types, often in a synergistic manner or by enhancing treatment efficacy (Table 1 and Fig