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Potential theoretical concerns include: Unregulated angiogenesis Immune system modulation Tumor growth acceleration under certain conditions Reproductive safety implications Cardiovascular remodeling There is no clinical evidence demonstrating these risks in humans, but comprehensive trials evaluating these endpoints do not exist

This localized reaction typically resolves within hours to a few days, but understanding what's normal versus what warrants provider contact is critical

Treating Underlying Conditions Managing digestive disorders or adjusting medications improves absorption

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The medication suppresses these biological drivers