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An example is thalidomide, a drug originally approved for treating pregnancy-induced morning sickness, sleeping problems and anxiety that was subsequently found to cause significant birth defects if taken during pregnancy (approximately 10,000 birth defects in Europe were attributed to the use of thalidomide by pregnant women in the 1960s)

The global sensitivity analysis also confirmed the importance of the redox cycle between SQ . and H 2 Q ( R 4 ), showing that the reverse rate constant, k m4 (SQ . reformation), was the second most sensitive (main interactions) with respect to model OCR and therefore ROS production, suggesting auto-oxidation is an essential part of the doxorubicin redox mechanism

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