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Vitamin D supplementation inhibits oxidative stress and upregulate SIRT1/AMPK/GLUT4 cascade in high glucose-treated 3T3L1 adipocytes and in adipose tissue of high fat diet-fed diabetic mice

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Doucette 9 , Magdy Elkhashab 13 , Philip Wong 14 and Mayur Brahmania 3 , (1)University of Western Ontario, (2)Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, (3)University of Calgary, (4)University of British Columbia, (5)University of Toronto, (6)Department of Medicine, University of Toronto, Toronto, ON, Canada, (7)Toronto General Hospital, Toronto, Ontario, Canada, (8)The Ottawa Hospital, Ottawa, ON, Canada, (9)Department of Medicine, University of Alberta, Edmonton, AB, Canada, (10)Bailey Health Center, Edmonton, AB, Canada, (11)Department of Internal Medicine, University of Manitoba, MB, Canada, (12)University of Saskatchewan, (13)Toronto Liver Center, Toronto, Ontario, Canada, (14)Department of Medicine, McGill University Health Centre, Montreal, QC, Canada Background: Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and the second-most frequent cause of malignancy-associated death

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After 24 weeks, PTEN KO developed 2.61.0 liver tumors, while glycine completely suppressed tumorigenesis to 00