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Triggering Factors Against a genetically predisposed background, certain triggering events can precipitate the onset or worsening of vitiligo: Intense emotional stress (grief, separation, psychological shock) particularly frequent Skin trauma : phenomenon of Koebner (appearance of spots on friction areas, cuts, burns, tattoos) Severe sunburn Pregnancy, childbirth, menopause (hormonal fluctuations) Viral or bacterial infections Certain medications (rare cases of induction by interferons, cancer immunotherapies) Key takeaway: vitiligo is never "the patient's fault"

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FOXP3 is a transcription factor essential for the development and function of CD4 + CD25 + Treg cells

Nat Rev Rheumatol 21 , 377395 (2025)

indications for activated charcoal in acetaminophen poisoning [1] Acetaminophen ingestion within 4 hours previously, due to prolonged absorption