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Environmental Geochemistry and Health, 38 (6), 12171227

these proteases degrade extracellular matrix (ECM) components, which facilitates cancer cell invasion, and cleave cell membrane-bound or ECM-associated precursor forms of many growth factors, thereby activating them and increasing their bioavailability in the tumour microenvironment

In assays measuring neurotrophic activity, Dihexa demonstrated potency seven orders of magnitude greater than BDNF, one of the brains primary growth factors

doi: 10.1375/twin.6.5.448 58

EGFR and c-MET have in common similar downstream pathways: MAPK (RAS/Rapidly accelerating fibrosarcoma (RAF)/ MAP kinase kinases (MEK)/ERK) and PI3K/AKT/mechanistic target of rapamycin (mTOR)