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Host defense relies on soluble and cellular pattern recognition receptors

Nanomedicines are delivered to tumours mainly through the EPR effect after intravenous administration

The molecule carries an -aminoisobutyric acid (Aib) substitution at position 2 that blocks DPP-IV cleavage, conferring complete resistance to the proteolytic step that inactivates native incretins within minutes

As a result, many patients develop post-viral insulin resistance, meaning their cells can no longer efficiently absorb glucose from the bloodstream to create energy

This is typically done when FDA-approved drugs dont work, often because of allergies, delivery methods or dosage strengths