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In large doses, it can cause digestive discomfort or facial flushing due to its high-fiber and niacin content, respectively

Furthermore, the increased reduction in the abundance of GPx3 in unaffected siblings of children with stage 3 as compared to children with a stage 1 sibling with the disease suggests that GPx3 levels may serve as an indicator for individuals within one household most at risk for developing the severe form of disease

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